博士，珠海科技学院药学与食品科学学院教师。本科毕业于中国矿业大学化工学院精细化工专业，硕士毕业于华东师范大学化学系有机化学专业，博士毕业于香港浸会大学化学系有机化学专业。先后在中国科学院上海有机化学研究所，澳门科技大学中药质量研究国家重点实验室，安锐生物医药科技（广州）有限责任公司从事研究工作。主要研究领域为小分子药物的设计和合成。参与研发的CDK2选择性抑制剂正在中美等地申请临床实验。先后完成了对小檗碱、蝙蝠葛碱、西红花酸、强心苷Uscharin、银杏内酯B等天然产物的结构改造，合成过crisaborole（特异性皮炎）， albenazine（成人迟发性运动障碍患者的药物）等药物类似物。参与多项国家自然基金及澳门科学技术发展基金。发表了学术论文19篇，其中SCI18篇。申请国际专利1项，美国专利2项（已授权1项），澳大利亚专利3项（已授权），国内专利7项。

教学工作(所授课程）：中药制剂分析

科研方向：小分子药物的设计和合成

代表性论文：

1. Run-Fen Li ^#; Xiao-Bo Zhou^#; Hong-Xia Zhou^#; Zi-Feng Yang; Hai-Ming Jiang; Xiao Wu; Wen-Jia Li; Jian-Jian Qiu; Jianing Mi; Ming Chen; Nan-shan Zhong; Guo-Yuan Zhu; Zhi-Hong Jiang; A novel fatty acid in Cordyceps suppresses influenza A (H1N1) virus-induced pro-inflammatory response through regulating innate signaling pathways. ACS Omega, 2021, 6, 1505-1515.

2. Xiaobo Zhou^#, Riping Xiao^#, Ming Chen, Li-Ping Bai^*, Synthesis of Uscharin Oxime Analogues and Their Biological Evaluation as HIF-1 Inhibitors. ChemistrySelect 2020, 12869-12872.

3. Xiaobo Zhou^#, Li Chen ^#, Zhi-Hong Jiang, Xiaoyi Chen, Pei Luo*, Li-Ping Bai* Synthesis of 21-alkylidenes and 21-alkylols analogues of uscharin and their roles in intracellular calcium in cardiac cells. ChemistrySelect 2019, 5512-5517.

4. Xiaobo Zhou¹, Yuan Qing Qu¹, Zhiyuan Zheng, Betty Yuen Kwan Law, Simon Wing Fai Mok, Zhi-Hong Jiang*, Vincent Kam Wai Wong*, Li-Ping Bai* Novel Dauricine Derivatives Suppress Cancer via Autophagy-dependent Cell Death. Bioorganic Chemistry 2019, 83, 450-460.

5. Xiaobo Zhou¹, Ming Chen¹, Zhiyuan Zheng, Guo-Yuan Zhu, Zhi-Hong Jiang^*, Li-Ping Bai^* Synthesis and evaluation of novel 12-aryl berberine analogues with hypoxia-inducible factor-1 inhibitory activity RSC advances 2017, 7, 26921-26929. 

6. Xiaobo Zhou, Yunguo Lu, Jian-Fa Zhu, Wing-Hong Chan*, Albert W. M. Lee, Pui-Shan Chan, Ricky N. S. Wong and N. K. Mak, Ratiometric fluorescent Zn²⁺ chemosensor constructed by appending a pair of carboxamidoquinoline on 1,2-diaminocyclohexane scaffold, Tetrahedron, 2011, 67, 3412-3419.

7. Xiaobo Zhou, Huimin Zhang, Xie Xin and Yanzhong Li , Efficient Synthesis of 3-Iodoinenes Via Lewis acid Catalyzed Friedel-Crafts cyclization of Iodonated Allylic Alcohols, J. Org. Chem. 2008, 73, 3958-3960.

8. Xiaobo Zhou, Huimin Zhang, Jiwei Yuan, Lugen Mai and Yanzhong Li*; Copper-catalyzed one-pot N-alkenylation and N-alkylation of amides: an efficient synthesis of substituted 2,3-dihydropyrroles, Tetrahedron Letters, 2007, 48, 7236–7239.